Table 2.
Regression coefficients (standard errors) and their p-values from fully adjusted models for lipid levels at index visit (visit after final menstrual period or surgery) and changes prior to and following index visit
| HDL* | LDL† | (log) Triglycerides | Apo‡A1 | ApoB | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Coefficient (SE)§ |
p-value | Coefficient (SE) |
p-value | Coefficient (SE) |
p-value | Coefficient (SE) |
p-value | Coefficient (SE) |
p-value | |
| Mean at index visit | ||||||||||
| Natural menopause (referent) |
59.39 (1.31) | — | 129.77 (3.01) | — | 2.05 (.02) | — | 170.99 (2.32) | — | 116.70 (2.64) | — |
| Hysterectomy with ovarian conservation |
58.06 (2.12) | .53 | 140.44 (5.01) | .03 | 2.07 (.03) | .47 | 174.22 (4.07) | .43 | 124.34 (4.19) | .07 |
| Hysterectomy with bilateral oophorectomy |
58.93 (1.97) | .82 | 126.33 (4.43) | .44 | 2.12 (.03) | .02 | 173.97 (3.66) | .42 | 117.20 (3.62) | .89 |
|
Mean annual rate of change from baseline to index visit |
||||||||||
| Natural menopause(referent) |
.09 (.10) | .35 | 3.68 (.26) | <.001 | .01 (.00) | <.001 | 2.07 (.24) | <.001 | .52 (.24) | .03 |
| Hysterectomy with ovarian conservation |
.82 (.57) | .20 | 3.95 (1.92) | .89 | −.01 (.01) | .04 | 5.18 (1.43) | .03 | −1.23 (1.99) | .38 |
| Hysterectomy with bilateral oophorectomy |
.25 (.54) | .76 | 2.64 (1.42) | .46 | −.01 (.01) | .85 | 2.83 (1.45) | .60 | .49 (1.18) | .98 |
|
Mean annual rate of change after index visit |
||||||||||
| Natural menopause (referent) |
−.82 (.15) | <.001 | 1.52 (.37) | <.001 | .01 (.00) | <.001 | 1.00 (.33) | <.001 | −.58 (.34) | .09 |
| Hysterectomy with ovarian conservation |
−.55 (.59) | .64 | 1.02 (1.78) | .78 | .02 (.01) | .40 | .06 (1.17) | .42 | −.62 (1.47) | .98 |
| Hysterectomy with bilateral oophorectomy |
−.50 (.62) | .61 | 3.44 (1.31) | .14 | .01 (.01) | .98 | 1.62 (1.45) | .67 | .98 (1.34) | .25 |
Models adjusted by site, race/ethnicity, educational attainment, age at FMP or surgery, menopausal status at visit prior to FMP or surgery, elapsed time between index visit and FMP or surgery (all time-invariant), and stroke or myocardial infarction, physical activity, antidepressant use (HDL, triglycerides), hormone therapy use, self-rated health, cholesterol medication use (HDL, LDL, triglycerides), and smoking status (time-varying). All covariates entered simultaneously.
P-values for natural menopause (referent) refer to significant difference from 0; p-values for hysterectomy with ovarian conservation and hysterectomy with bilateral oophorectomy refer to significant difference from natural menopause.
LDL-C (low density lipoprotein cholesterol)
HDL-C (high density lipoprotein cholesterol)
Apo (apolipoprotein)
SE (Standard Error)