Table 3.
Regression coefficients (standard errors) and their p-values from fully adjusted models for other cardiovascular risk factor levels at index visit (visit after final menstrual period or surgery) and changes prior to and following index visit
| (log) HOMA-IR* | Systolic Blood Pressure |
TPA-ag‡ | PAI-1‡ | Factor VIIc | CRP§ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coefficient (SE)** |
p- value |
Coefficient (SE) |
p- value |
Coefficient (SE) |
p- value |
Coefficient (SE) |
p- value |
Coefficient (SE) |
p- value |
Coefficient (SE) |
p- value |
|
|
Mean at index visit |
||||||||||||
|
Natural Menopause (referent) |
.30 (.02) | — | 111.58 (1.23) |
— | 8.04 (.84) | — | 24.68 (3.14) | — | 129.77 (3.06) |
— | 2.97 (.54) | — |
|
Hysterectomy with ovarian conservation |
.32 (.04) | .58 | 112.56 (2.06) |
.63 | 7.68 (.78) | .64 | 21.40 (4.83) | .50 | 154.08 (21.56) |
.26 | 3.77 (.83) |
.33 |
|
Hysterectomy with bilateral oophorectomy |
.29 (.03) | .78 | 114.14 (1.66) |
.12 | 8.23 (1.09) | .86 | 26.15 (4.80) | .76 | 131.76 (5.19) |
.70 | 4.20 (.77) | .11 |
|
Mean annual rate of change from baseline to index visit |
||||||||||||
|
Natural menopause (referent) |
.00 (.00) | .06 | .40 (.12) | <.001 | .24 (.08) | <.01 | −1.94 (.57) | <.001 | 1.27 (.39) | <.01 | −.15 (.06) | .02 |
|
Hysterectomy with ovarian conservation |
.00(.02) | .88 | −.38 (1.19) | .51 | −.39 (.20) | <.01 | −1.73 (1.92) | .92 | 7.41 (6.40) | .34 | −.97 (1.33) | .53 |
|
Hysterectomy with bilateral oophorectomy |
.00 (.01) | .86 | 1.04 (.61) | .30 | .40 (.30) | .60 | −.27 (1.90) | .38 | −.80 (1.97) | .29 | .58 (.25) | <.01 |
|
Mean annual rate of change after index visit |
||||||||||||
|
Natural menopause (referent) |
.02 (.00) | <.001 | .01 (.10) | .92 | .27 (.22) | .23 | −2.54 (.53) | <.001 | −.33 (.59) | .58 | .14 (.08) | .07 |
|
Hysterectomy with ovarian conservation |
.01 (.01) | .42 | .02 (.34) | .98 | .15 (.27) | .67 | −1.67 (1.81) | .63 | −8.27 (9.31) | .40 | −.19 (.25) | .18 |
|
Hysterectomy with bilateral oophorectomy |
.02 (.01) | .88 | −.02 (.36) | .93 | −.18 (.36) | .21 | −3.21 (1.72) | .69 | −.50 (2.22) | .94 | .03 (.22) | .61 |
Models adjusted by site, race/ethnicity, educational attainment, age at FMP or surgery, menopausal status at visit prior to FMP or surgery, elapsed time between index visit and FMP or surgery (all time-invariant), and stroke or myocardial infarction, heart medication use (systolic blood pressure, TPA, PAI-1, factor VIIc), physical activity, antidepressant use (HOMA-IR, PAI-1, FactorVIIc, CRP), hormone therapy use, smoking status, and antihypertensive medication use (systolic blood pressure) (time-varying). All covariates entered simultaneously.
P-values for natural menopause (referent) refer to significant difference from 0; p-values for hysterectomy with ovarian conservation and hysterectomy with bilateral oophorectomy refer to significant difference from natural menopause.
CRP(C-reactive Protein)
HOMA-IR (Homeostasis Model of Assessment –Resistance)
PAI-1 (Plasminogen activator inhibitor-1)
tPA-ag (Tissue plasminogen activator- antigen)
SE (standard error)