Table 2. Changes in cardiopulmonary variables.
Time after injury (hours) | |||||||
---|---|---|---|---|---|---|---|
|
|||||||
0 | 6 | 12 | 18 | 24 | 36 | 48 | |
MAP, mmHg | |||||||
Sham | 96 ± 3 | 107 ± 3 | 103 ± 4 | 103 ± 2 | 100 ± 2 | 97 ± 4 | 96 ± 3 |
Control | 96 ± 3 | 114 ± 6 | 105 ± 5 | 103 ± 4 | 102 ± 5 | 102 ± 6 | 104 ± 5 |
Treatment | 94 ± 4 | 116 ± 5 | 113 ± 7 | 111 ± 5 | 107 ± 5 | 103 ± 3 | 106 ± 5 |
HR, bpm | |||||||
Sham | 83 ± 3 | 92 ± 3 | 117 ± 10 | 113 ± 8 | 107 ± 5 | 101 ±5 | 90 ± 3 |
Control | 91 ± 5 | 124 ± 10a | 118 ± 6 | 145 ± 7a | 148 ± 6a | 153 ± 8a | 131 ± 5a |
Treatment | 99 ± 4 | 125 ± 9a | 139 ± 12 | 126 ± 9 | 122 ± 2 | 132 ± 7a | 129 ± 5a |
CI, l/min/m2 | |||||||
Sham | 6.3 ± 0.2 | 7.3 ± 0.2 | 7.1 ± 0.4 | 7.2 ± 0.4 | 6.4 ± 0.4 | 7.5 ± 0.6 | 6.0 ± 0.5 |
Control | 6.4 ± 0.2 | 7.4 ± 0.5 | 6.6 ± 0.8 | 7.1 ± 0.6 | 6.3 ± 0.5 | 6.6 ± 0.7 | 6.7 ± 0.4 |
Treatment | 6.5 ± 0.3 | 6.6 ± 0.5 | 7.7 ± 0.9 | 7.0 ± 0.5 | 7.2 ± 0.6 | 7.3 ± 0.2 | 7.6 ± 0.7 |
LAP, mmHg | |||||||
Sham | 9 ± 0 | 12 ± 2 | 13 ± 2 | 11 ± 1 | 11 ± 1 | 11 ± 1 | 11 ± 1 |
Control | 8 ± 1 | 10 ± 1 | 9 ± 1 | 11 ± 1 | 11 ± 1 | 10 ± 1 | 12 ± 2 |
Treatment | 9 ± 0 | 11 ± 1 | 11 ± 1 | 12 ± 1 | 12 ± 1 | 11 ± 1 | 10 ± 1 |
PCWP, mmHg | |||||||
Sham | 11 ±0 | 16 ± 1 | 17 ± 1 | 16 ± 1 | 15 ± 1 | 16 ± 1 | 16 ± 1 |
Control | 11 ± 1 | 14 ± 1 | 14 ± 1 | 16 ± 1 | 16 ± 1 | 14 ± 1 | 14 ± 1 |
Treatment | 13 ± 0 | 16 ± 1 | 17 ± 1 | 17 ± 1 | 17 ± 1 | 17 ± 0 | 15 ± 0 |
MPAP, mmHg | |||||||
Sham | 19 ± 0 | 28 ± 1 | 28 ± 1 | 27 ± 0 | 25 ± 1 | 29 ± 1 | 25 ± 1 |
Control | 19 ± 1 | 26 ± 1 | 26 ± 2 | 27 ± 1 | 29 ± 1 | 27 ± 1 | 28 ± 2 |
Treatment | 21 ± 0 | 29 ± 2 | 27 ± 2 | 27 ± 2 | 27 ± 1 | 27 ± 1 | 26 ± 1 |
CI, cardiac index; HR, heart rate; LAP, left atrial pressure; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PCWP, pulmonary capillary wedge pressure. The data are expressed as mean ± SEM.
P < 0.05 vs. sham;
P < 0.05 treatment vs. control.