Table 1.

Inclusion filters and papers eliminated by each filter for the pubmed.gov search.

Filter	Description	Justification	Number of papers	Number eliminated
Internet search	[(“Temporal Lobe Epilepsy” OR TLE) AND (voxel OR “voxel-based morphometry” OR VBM)]		164
Relevance	Published in English-language, peer-reviewed journals; reporteda x–y–z foci from whole-brain VBM (modulated or unmodulated) analyses in MNI or T&T space	Standard relevance criteria (Fox et al., 2005a,b)	164	142
MTLE-HS diagnosis	Pre-surgical adult MTLE with unilateral HS verified with EEG, structural MRI, and/or post-surgical histology	The majority of papers reported this diagnostic criteria	22	1
Experimental Contrast	Analyses of gray matter reduction in separate R and L-MTLE populations compared to healthy controls, unregressed for other variables. (P < 0.05, uncorr. or more stringent)	Excluded analyses included white matter reduction, R vs L-MTLE, and regressions for aura, disease duration, etc.	21	8
Non-redundancy	Only one contrast per paper per group per patient population	Some groups reported multiple analyses of a patient population within and across papers	13	2
TOTAL			11

TLE = temporal lobe epilepsy; VBM = voxel-based morphometry; MNI = Montreal Neurological Institute; T&T = Talairach and Tournoux; MTLE = medial temporal lobe epilepsy; HS = hippocampal sclerosis; R = right; L = left.

^aUpon request, Pell et al. (2008) supplied previously unreported foci.