Table 2.
Overview of included studies.
| Paper | n (L-MTLE) | n (R-MTLE) | n (controls) | Agea | L-MTLE focib | R-MTLE focib | VBM analysis | Smoothing kernel | Significance levelc | Diagnosis of TLE according tod | Unilateral HS? | Patient type | Software: template |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bernasconi et al., 2004 | 45 | 40 | 47 | 35 ± 10 | 26 | 13 | UM | 5 mm FWHM | P (corr.) < 0.05 | video-EEG monitoring + HS | Yes | Unspecified | INSECT: MNI |
| Bonilha et al., 2004 | 22 | 21 | 49 | 32 ± 8 | 20 | 14 | UM | Unspecified | P (uncor.) < .05 | 89' ILAE Criteria | Yes | Outpatients | SPM2: MNI |
| Bouilleret et al., 2008 | 12 | 0 | 30 | 36 ± 10 | 12 | 0 | M | 12 mm FWHM | P (uncorr.) < 0.001 | EEG-monitor; structural MRI | Yes | Unspecified | SPM2:T&T |
| Keller et al., 2002 | 58 | 58 | 58 | 34 | 14 | 13 | UM | 10 mm FWHM | P (corr.) < 0.05 | Scalp + Invasive EEG | Unspecified | Pre-surgical | SPM99:T&T |
| McMillan et al., 2004 | 13 | 12 | 62 | 32.2 ± 11 | 7 | 15 | M | 12 mm FWHM | P (corr.) < 0.05 | video-EEG monitoring + HS | Yes | Pre-Surgical | SPM2: MNI |
| Mueller et al., 2006 | 0 | 26 | 30 | 35.6 ± 9.7 | 0 | 33 (R + Rct L) | M + UM | 8 mm FWHM | P (corr.) < 0.05 | Video-EEG Telemetry | Yes | Pre-surgical | SPM2: MNI |
| Pail et al., 2010 | 20 | 20 | 40 | 39.5 ± 9.7 | 6 | 11 | M | Unspecified | P (corr.) < 0.001, 100 voxels | 89' ILAE Criteria | Yes | Unspecified | SPM2: MNI |
| Pell et al., 2008 | 19 | 0 | 115 | 39.3 ± 12 | 18 | 0 | M | 6 mm FWHM | P (corr.) < 0.05 | Institutional Criteria | Yes | Pre-surgical | SPM2: MNI |
| Riederer et al., 2008 | 9 | 13 | 12 | 38 ± 11 | 10 | 3 | M | 4 mm FWHM | P (uncorr.) < 0.001 | Video-EEG + HS | Yes | Pre-surgical | SPM2: MNI |
| Santana et al., 2010 | 59 | 41 | 30 | 37.29 | 16 | 10 | M | 8 mm FWHM | P (uncorr.) < 0.001 | Video-EEG Telemetry | Yes | Pre-surgical | SPM5: MNI |
| Tae et al., 2010 | 16 | 15 | 47 | R: 29 L: 33 |
28 | 31 | M + UM | 8 mm FWHM | P (corr.) < 0.05 | EEG monitoring + HS | Yes | Pre-surgical | SPM2: MNI |
| Total | 273 | 246 | 520 | 157 | 143 |
L-MTLE = left medial temporal lobe epilepsy; R-MTLE = right medial temporal lobe epilepsy; MNI = Montreal Neuroimaging Institute; FWHM = Full Width at Half Maximum; Corr. = corrected; Uncorr. = Uncorrected; HS = hippocampal sclerosis; UM = unmodified; M = Modified; Rct = Rectified (consult methods for further explanation); T&T = Talairach and Tournoux.
a
Of MTLE patients. Presented in mean ± SD(range) years.
b
Foci listed report gray matter reduction only.
c
Significance levels reported on whole-brain level.
d
Terminology used in the original articles.