Table 3.
Risk of invasive and borderline ovarian tumors, by age at reference date, in association with working the nightshift
<50 years of age at reference date | ≥50 years of age at reference date | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||||||
Invasive | Borderline | Invasive | Borderline | |||||||||||||
| ||||||||||||||||
Controls (%)(n=444) | Cases (%)(n=274) | ORa (95% CI) | Cases (%)(n=172) | ORa (95% CI) | Controls (%)(n=1388) | Cases (%)(n=827) | ORa (95% CI) | Cases (%)(n=217) | ORa (95% CI) | |||||||
Worked nightshift | ||||||||||||||||
Never | 326 | (73.4) | 197 | (71.9) | 113 | (65.7) | 1094 | (78.8) | 611 | (78.8) | 150 | (69.1) | ||||
Ever | 118 | (26.6) | 77 | (28.1) | 1.0 (0.69–1.44) | 118 | (26.6) | 1.38 (0.92–2.05) | 294 | (21.2) | 216 | (21.2) | 1.32 (1.07–1.63) | 67 | (30.1) | 1.57 (1.13–2.19) |
Cumulative nightshift work-years | ||||||||||||||||
Never | 326 | (73.4) | 197 | (71.9) | 113 | (65.7) | 1094 | (78.8) | 611 | (73.9) | 150 | (69.1) | ||||
4mos-1 yr | 26 | (5.9) | 16 | (5.8) | 1,06 (0.52–2.15) | 12 | (7.0) | 1.28 (0.61–2.71) | 71 | (5.1) | 39 | (4.7) | 0.98 (0.65–1.49) | 15 | (6.9) | 1.51 (0.83–2.76) |
>1–3 yrs | 44 | (9.9) | 22 | (8.0) | 0.82 (0.45–1.49) | 20 | (11.6) | 1.28 (0.70–2.34) | 77 | (5.6) | 53 | (6.4) | 1.26 (0.89–1.84) | 15 | (6.9) | 1.32 (0.73–2.40) |
>3–7 yrs | 24 | (5.4) | 28 | (10.2) | 1.52 (0.81–2.87) | 22 | (12.8) | 2.36 (1.22–4.57) | 61 | (4.4) | 66 | (8.0) | 2.04 (1.40–2.97) | 22 | (10.1) | 2.34 (1.36–4.01) |
>7 yrs | 24 | (5.4) | 11 | (4.0) | 0.67 (0.30–1.51) | 5 | (2,9) | 0.63 (0.22–1.74) | 84 | (6.1) | 57 | (7.0) | 1.16 (0.80–1.66) | 15 | (6.9) | 1.29 (0.71–2.33) |
unknown | 0 | (0) | (0) | (0) | - | 0 | (0) | - | 1 | (<1) | 1 | (<1) | - | 0 | (0) | - |
Reference date is the date of diagnosis among cases and a comparable assigned date among controls
Adjusted for age at reference, county, reference year, duration of oral contraceptive use, number of full term pregnancies, and BMI at age 30