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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Biochem Pharmacol. 2013 Aug 5;86(6):824–835. doi: 10.1016/j.bcp.2013.07.023

Figure 6. Compounds 5, 6, and 8 are PXR antagonists.

Figure 6

HepG2 cells transiently transfected with hPXR, CYP3A4-luc, and CMV-Renilla were treated for 24 h with 5 μM of rifampicin and indicated concentrations of compound 5, 6, or 8 prior to luciferase assay (A–C). HepG2 cells transiently transfected with hPXR, CYP3A4-luc, and CMV-Renilla were treated for 24 h with indicated concentrations of compounds prior to luciferase assay (D–F).