Figure 9. Compound 1 activate PXR-regulated CYP2B6 promoter activity in HepG2 cells.
HepG2 cells transiently transfected with hPXR, CYP2B6-luc, and CMV-Renilla were treated for 24 h with indicated concentrations of rifampicin or compound 1 prior to luciferase assay.