Table 1.
Baseline Characteristics of Study Groups
| Characteristics | Cirrhotic cases | Cirrhotic controls | Noncirrhotic controls | P |
|---|---|---|---|---|
| N | 91 | 153 | 89 | |
| Age, y (range) | 55 (24–84) | 53 (19–89) | 59 (20–91) | .01 |
| Male gender, n (%) | 61 (67) | 102 (67) | 48 (54) | .097 |
| Race, n (%) | .432 | |||
| Caucasian | 78 (86) | 125 (82) | 67 (75) | |
| African American | 10 (11) | 20 (13) | 19 (21) | |
| Other | 3 (3) | 8 (5) | 3 (3) | |
| Mean arterial pressure, mm Hg (range) | 82 (40–123) | 91 (68–137) | 92 (59–123) | <.001a |
| Heart rate, bpm (range) | 82 (20–121) | 76 (53–110) | 80 (44–124) | .02b |
| Etiology of cirrhosis | <.001 | |||
| Alcoholic (alone or associated with viral), n (%) | 49 (54) | 40 (26) | ||
| Nonalcoholic, n (%) | 42 (46) | 113 (74) | ||
| Hepatitis C and/or B, n | 28 | 70 | ||
| Cholestatic liver disease (PBC or PSC), n | 2 | 12 | ||
| Other, nc | 12 | 31 | ||
| Total bilirubin, mg/dL (range) | 2.6 (0.5–50.9) | 1.0 (0.1–6.76) | — | <.001 |
| Albumin, g/dL (range) | 2.7 (0.7–4.9) | 3.7 (1.7–5.0) | — | <.001 |
| INR (range) | 1.70 (1.07–7.13) | 1.24 (0.81–1.53) | — | <.001 |
| CTP score (range) | 9 (5–15) | 6 (5–12) | — | <.001 |
| CTP class, n (%) | <.001 | |||
| A | 7 (8) | 107 (70) | — | |
| B | 41 (45) | 40 (26) | — | |
| C | 43 (47) | 5 (3) | — | |
| Past cirrhosis decompensation, n (%) | 42 (46) | 40 (26) | — | .001 |
| Liver medication compliance, % | 89 | 93 | — | .1 |
PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis.
a
Significantly different between cirrhotic cases and both control groups.
b
Significantly different between cirrhotic controls and the other 2 groups.
c
Includes hemochromatosis, autoimmune hepatitis, drug-induced (methotrexate in 1 patient), nonalcoholic steatohepatitis, sarcoidosis, Budd-Chiari, and cryptogenic.