Table 1.

Data collection and refinement statistics

	Lgr4	Lgr4	Complex
	Native	(NH4)2PtCl4 (SAD)	Lgr4/Rspo1
Resolution range (Å)	113.8 - 2.66 (2.8 - 2.66)	49.53 - 2.92 (3.08 - 2.92)	50 - 3.2 (3.31 - 3.2)
Space group	C 2 2 21	P 4 21 2	C 2 2 21
Unit cell	60.29 158.582 227.609 90 90 90	152.615 152.615 111.458 90 90 90	103.379 160.923 82.216 90 90 90
Total reflections	202138	384476	51022
Unique reflections	31899	35527	11576
Multiplicity	6.3 (6.4)	13.1 (13.7)	4.4 (4.4)
Completeness (%)	99.76 (99.87)	99.31 (99.28)	98.34 (96.29)
Mean I/sigma(I)	12.57 (1.77)	16.32 (1.83)	10.00 (1.43)
Wilson B-factor	64.49	75.15	94.06
R-merge	0.088 (0.872)	0.096 (1.364)	0.087 (0.966)
R-work	0.2375 (0.3584)		0.2560 (0.3981)
R-free	0.2732 (0.4375)		0.2938 (0.4582)
Number of atoms	6807		4041
macromolecules	6601		4027
ligands	28		14
water	178		0
Protein residues	851		526
RMS(bonds)	0.005		0.003
RMS(angles)	1.18		1.00
Ramachandran favored (%)	97		92
Ramachandran outliers (%)	0		0
Clashscore	14.14		13.15
Average B-factor	66.60		70.60
macromolecules	66.80		70.50
ligands	75.80		93.40
solvent	58.90

Statistics for the highest-resolution shell are shown in parentheses.