Fig. 1.

Seed-based correlation maps comparing TLE patients to controls for seeds in ipsilateral medial temporal regions. The left column shows the seed, while the remaining columns show the Z-score maps at selected axial slices. Slice labels are in Talairach coordinates (Talairach and Tournoux, 1988). The hemisphere ipsilateral to the seizure focus is mapped on the left (“I”) while the contralateral hemisphere is mapped on the right (“C”). Illustrated clusters are significant (p < .01) after correction for multiple comparisons. Blue–green colors indicate decreased correlations in patients, red–yellow indicate increased correlations. Ipsilateral hippocampal head, body and parahippocampus but not amygdala show significant functional decoupling with their contralateral homologues in TLE patients. The ipsilateral hippocampal head also shows increased functional coupling with the ipsilateral insula.