Figure 4. Inhaled RO 25-1553 does not increase lung water content in vivo.

Group data showing lung wet-to-dry weight ratio as a measure of lung edema in rats after normoxic (21% O₂, black bars) or hypoxic (11% O₂, open bars) ventilation for 70 min and a 3 min inhalation of either 0.9% NaCl, RO 25-1553 (1 mg·mL⁻¹) or sildenafil (10 mg·mL⁻¹) 60 min prior to tissue harvesting. Data are means+SEMs; * p<0.05 vs. corresponding normoxia group, n = 8 experiments each.