Table 1. Representative raw data for the pressure-flow (P-Q) relationships in isolated perfused mouse lungs at different experimental conditions.

group		control		RO 25-1553						sildenafil
concentration		-		0.01 mg·ml−1		0.1 mg·ml−1		1 mg·ml−1		100 nmol/l−1
FiO2		0.21	0.01	0.21	0.01	0.21	0.01	0.21	0.01	0.21	0.01
PAP	25 ml·kg−1·min−1	4.38	4.91	4.27	4.57	3.82	3.94	3.95	4.02	3.80	3.93
PAP	50 ml·kg−1·min−1	5.85	6.77	5.88	6.83	5.69	6.12	5.52	5.85	5.56	5.94
PAP	75 ml·kg−1·min−1	7.32	8.40	7.12	8.13	7.14	7.56	6.97	7.24	6.71	7.17
PAP	100 ml·kg−1·min−1	8.32	9.47	8.16	9.06	8.22	8.58	8.22	8.49	7.85	8.36
R0		0.17	0.23	0.18	0.23	0.11	0.13	0.10	0.12	0.11	0.12

Representative pulmonary artery pressures (PAP; in mmHg) as recorded in individual isolated mouse lungs perfused at flow rates (Q) of 25, 50, 75, and 100 ml·kg⁻¹·min⁻¹ and corresponding intrinsic pulmonary vascular resistance values (R₀; in mmHg·ml⁻¹·kg⁻¹·min⁻¹) as calculated from the respective 4-point P-Q curve. Examples are given for normoxic (21% O₂) or hypoxic (1% O₂) lungs perfused with buffer alone (control), with RO 25-1553 at final concentrations of 0.01, 0.1 or 1 mg·mL⁻¹, or with sildenafil (100 nMol·L⁻¹). FiO₂; fraction of inspiratory O₂ (0.21 for normoxia; 0.01 for hypoxia).