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. 2013 Sep 19;7(9):e2438. doi: 10.1371/journal.pntd.0002438

Table 2. Temephos resistance candidate genes ranked according to the fold change in expression between CucR and CucU, with detoxification genes shown in bold.

Fold change
Systematic name Description CucR-NO CucR-BB CucR-CucU CucP-CucR
AAEL011230-RA Chymotrypsin, putative 87.14 28.37 30.21 −122.93
AAEL011167-RA Cathepsin l 5.44 17.50 13.21 −4.32
AAEL001418-RA Conserved hypothetical protein 26.24 4.70 13.00 −28.75
AAEL003076-RA Glucosyl/glucuronosyl transferase 13.65 16.09 10.38 −22.37
AAEL015657-RA Conserved hypothetical protein 14.54 13.51 8.14 −10.77
AAEL013263-RA High affinity copper transporter, putative 4.41 9.73 6.73 −11.13
AAEL014843-RA Heat shock protein 11.50 6.21 5.87 −3.21
AAEL011175-RA Alkaline phosphatase 6.18 12.77 5.70 −7.80
AAEL000813-RA Dimethylaniline monooxygenase 3.23 2.54 5.39 −6.71
AAEL015010-RA Acetyl-coa synthetase 7.12 5.27 5.23 −5.23
AAEL015070-RA Alkaline phosphatase 5.08 13.50 5.09 −6.85
AAEL006820-RA Lipid storage droplets surface binding protein 2 (lsd2) 4.72 4.03 4.78 −2.49
AAEL001194-RA Fatty acid synthase 5.47 3.23 4.14 −4.55
AAEL011704-RA Heat shock protein 8.23 2.20 4.13 −3.05
AAEL007799-RA Regulator of chromosome condensation 3.74 2.21 3.46 −2.88
AAEL007799-RB Regulator of chromosome condensation 3.74 2.27 3.46 −2.83
AAEL004455-RA Conserved hypothetical protein 3.62 2.16 3.12 −2.72
AAEL008651-RA Conserved hypothetical protein 3.45 28.44 3.12 −3.97
AAEL008844-RA Calcium-binding protein, putative 2.41 4.62 3.08 −5.07
AAEL008723-RA Conserved hypothetical protein 4.36 2.01 2.92 −2.62
AAEL005045-RA ATP-dependent bile acid permease 3.38 2.61 2.89 −7.49
AAEL000520-RA Conserved hypothetical protein 5.77 2.95 2.58 −3.46
AAEL012185-RA Ribosome biogenesis regulatory protein 2.93 2.77 2.58 −2.46
AAEL010118-RA Kelch repeat protein 3.20 2.03 2.57 −2.29
AAEL012100-RA Conserved hypothetical protein 3.18 3.11 2.43 −2.47
AAEL013406-RA Venom allergen 7.90 4.23 2.42 −9.90
AAEL005991-RA Tricarboxylate transport protein 2.21 4.37 2.38 −3.10
AAEL003654-RA Conserved hypothetical protein 3.41 2.19 2.38 −2.16
AAEL009124-RA Cytochrome P450 CYP6N12 3.98 4.40 2.34 −4.77
AAEL009127-RA Cytochrome P450 CYP6M11 3.82 3.13 2.32 −2.25
AAEL007271-RA Basic helix-loop-helix zip transcription factor 4.97 4.11 2.30 −3.41
AAEL012866-RA Conserved hypothetical protein 3.88 4.38 2.29 −3.31
AAEL008281-RA Conserved hypohetical protein 2.73 3.37 2.28 −5.23
AAEL003949-RA Conserved hypothetical protein 2.50 2.55 2.26 −2.06
AAEL008124-RA Possible RNA methyltransferase, putative 2.92 2.55 2.25 −2.01
AAEL000300-RA WD-repeat protein 2.71 2.09 2.24 −2.08
AAEL013946-RA Conserved hypothetical protein 3.88 5.35 2.17 −2.61
AAEL004063-RA WD-repeat protein 2.90 2.50 2.08 −2.07
AAEL002913-RA Peroxisomal membrane protein 70 abcd3 4.41 2.47 1.74 −2.39
AAEL014684-RA Cytochrome P450 CYP6F3 3.35 7.22 1.71 −4.68
AAEL001813-RA Sodium/solute symporter 3.08 2.70 1.66 −2.11

P-values and corrected P-values are shown in Table S3c.