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. 2013 Sep 19;8(9):e75319. doi: 10.1371/journal.pone.0075319

Figure 6. IgE levels are increased in the serum of SLE patients.

Figure 6

The quantification of IgG and IgE levels in the serum of inactive SLE patients (n = 17), active SLE patients (n = 6) and sex and age-matched healthy controls (n = 21) were determined by a sandwich ELISA assay. Results are expressed as the mean IgG concentration (g/L; A) or IgE concentration (ng/ml; B) from duplicate wells and correlation between IgG levels and TFH2 cell frequency is represented (A). Each data point represents an individual subject and horizontal lines show the mean ± sem. * p < 0.05, **p < 0.01 (unpaired Student’s t test and Pearson correlation coefficient). ns: not significant. ANA IgE in sera were detected using Hep-2 cells as substrate (C). Compared to healthy individual sera (HC, shown as an example), some IgG-depleted sera from lupus patients (4/12) (SLE, 1 out of 4 representative picture) yielded homogeneous nuclear staining.