Table 1. Data collection and refinement statistics ^a .

	Wild-type	E295Q/sucrose	D241A/glucose
PDB ID	4HOW	4HPH	4HOZ
Data Collection
Resolution range (Å)	45.1-1.70	35.0-1.70	31.8-2.00
	(1.76-1.70)	(1.76-1.70)	(2.07-2.00)
Space group	P212121	P212121	P212121
a, b, c (Å)	58.9, 81.3, 138.0	58.6, 81.1, 138.4	58.7, 82.5, 137.9
Redundancy	4.4 (3.0)	6.0 (5.9)	6.6 (6.3)
Completeness (%)	97.8 (84.0)	99.2 (99.0)	98.5 (97.0)
No. of reflections (unique)	609771 (72135)	434369 (72577)	299859 (45383)
I/σ	20.4 (5.0)	13.0 (3.7)	18.6 (2.8)
R merge b	0.075 (0.509)	0.112 (0.572)	0.084 (0.491)
Molecules in the AU	1	1	1
Refinement
R work c/R free d	0.156/0.188	0.167/0.198	0.147/0.197
Average B factor (Å2)	20.0	19.4	26.2
RMSD bonds (Å)	0.006	0.006	0.008
RMSD angles (°)	1.04	1.05	1.03
Ramachandran statisticse	97.16%, 2.84%, 0%	97.16%, 2.84%, 0%	97.15%, 2.85%, 0%

^aValues in parentheses are for the highest resolution shell.

^b $R_{\text{merge}}={\sum }_{\text{hkl}}{\sum }_{\text{i}}\left|I\right(hkl;i)–<I(hkl)>|/{\sum }_{\text{hkl}}{\sum }_{\text{i}}I(hkl;i)$, where I(hkl;i) is the intensity of an individual measurement of a reflection and $<I\left(hkl\right)>$ is the average intensity of that reflection.

^c $R_{\text{work}}=[\sum |\left(F_{\text{obs}}\right)–k\left(F_{\text{calc}}\right)]/\sum \left|\left({\text{F}}_{\text{obs}}\right)\right|],$ where k is a scale factor and the test set has been removed.

^d R _free is defined as the R _work calculated for 9% of the X-ray data selected randomly, and excluded from refinement.

^eRamachandran statistics indicate the fraction of residues in the most favored, allowed, and disallowed regions of the Ramachandran diagram, respectively.