Figure 1. Effects of exenatide and piragliatin on beta cell death in INS-1.

(A) INS-1 cells, serum-starved overnight, were pre- and post-treated with each drug with or without 2 mM STZ for 1 h. (B) INS-1 cells serum-starved overnight were treated with or without 0.8 mM palmitate for 24 h. (C) INS-1 cells serum-starved overnight were treated in the absence or presence of each drug, with or without 0.3 µM Tg for 6 h. At the end of each experiment, cell viability was assessed by cytosolic ATP levels and data from three individual experiments were presented as mean ± S.E. *, P<0.05 vs. control in the absence of each death inducer; #, both P<0.05 vs. control in the presence of palmitate by Bonferroni's post hoc analysis.