Table 2. Statistical measure of performance in accurately detecting true field potential complexes in arrhythmogenic and morphology changing signals using cross correlation with CF = 0.98.

MEA recording from hiPSC-CMs	TP	FP	TN	FN	PPV	Sensitivity	Specificity
Arrhythmogenic signals
E-4031 – 10 nM	141	0	9	0	100%	100%	100%
E-4031 – 100 nM	281	3	24	2	98.94%	99.34%	88.89%
E-4031 – 700 nM	59	3	24	0	95.16%	100%	88.89%
E-4031 – 700 nM	22	2	51	0	91.67%	100%	96.23%
Morphology changing signals
E-4031 400 nM + Esmolol 84 µM	38	2	18	0	95%	100%	90%
E-4031 – 700 nM + Esmolol 84 µM	37	2	71	2	94.87%	94.87%	97.26%
E-4031 – 700 nM + Esmolol 168 µM	37	1	167	0	97.36%	100%	99.41%
E-4031 – 1000 nM+ Esmolol 168 uM	44	1	20	0	97.78%	100%	95.24%
Average:					96.35%	99.27%	94.49%

CF-Correlation factor, TP-True positive, FP-False positive, TN-True negative, FN-False negative, PPV-Positive predictive value.

Sensitivity, specificity and PPV show consistent results for different datasets of arrhythmogenic and morphology changing signals. Results indicate that the correlation analysis is highly sensitive and specific in detecting field potential complexes. A mean PPV of 96.35% indicates that true field potential complexes are detected with a high degree of accuracy, irrespective of the type of signal being analysed.