Table 4. Colonization and infection with the 6A clone.
| Colonization and infection1
|
|||||||
|---|---|---|---|---|---|---|---|
| Time (Days) | Mice | Nasopharynx | Olfactory bulbs | Brain | Lungs | Middle ear | Blood |
| 2 | 5 | 100% | 100% | 60% | 60% | 60% | 0% |
| 7 | 6 | 100% | 100% | 83% | 0% | 17% | 0% |
| 14 | 6 | 67% | 50% | 0% | 0% | 17% | 0% |
| 21 | 7 | 57% | 43% | 29% | 14% | 0% | 0% |
| Total | 24 | 79% | 71% | 42% | 17% | 21% | 0% |
| Total CFU recovered2 | |||||||
| Time (Days) | Mice | Nasopharynx | Olfactory bulbs | Brain | Lungs | Middle ear | Blood |
| 2 | 5 | 7.7E+04 | 1.8E+03 | 7.8E+01 | 5.8E+01 | 3.4E+01 | 0.0E+00 |
| 7 | 6 | 2.7E+04 | 4.3E+02 | 4.8E+02 | 0.0E+00 | 1.8E+00 | 0.0E+00 |
| 14 | 6 | 8.8E+02 | 1.2E+01 | 0.0E+00 | 0.0E+00 | 1.2E+00 | 0.0E+00 |
| 21 | 7 | 1.3E+03 | 5.0E+00 | 7.9E+00 | 3.7E+00 | 0.0E+00 | 0.0E+00 |
| Total | 24 | 2.7E+04 | 5.6E+02 | 1.4E+02 | 1.6E+01 | 9.4E+00 | 0.0E+00 |
At day 2, 7, 14, and 21 after intranasal inoculation (10µL) of the mice, several tissues (nasopharynx, olfactory bulbs, brain, lungs, middle ear and blood) were sampled to assess for the presence of live pneumococci.
1 Percentage of mice presenting pneumococci in the different tissues.
2 Average number of CFUs per mouse in the different tissues.