Table 1. Summary of anakinra and dexamethasone sensitivity profiles.

	NO2-promoted allergic airway disease			Th17 adoptive transfer			Th2 adoptive transfer			Anti-IL-4 in NO2-promoted allergic airway disease
Cytokine	Ana	Dex	Ana+ Dex*	Ana	Dex	Ana+ Dex*	Ana	Dex	Ana+ Dex*	Ana	Dex	Ana+ Dex*
IL-17A	S	S	S	R	R	S	S	S	R	S	S	S
IL-17F	S	S	S	R	R	S	NM	NM	NM	NM	NM	NM
IL-21	ND	ND	ND	R	R	R	NM	NM	NM	NM	NM	NM
IL-22	S	S	S	R	R	S	NM	NM	NM	NM	NM	NM
GM-CSF	S	S	R	S	S	R	NM	NM	NM	NM	NM	NM
IL-5	R	S	R	R	S	R	R	S	R	R	S	R
IL-13	R	S	R	S	S	R	R	S	R	R	S	R
IFNγ	S	S	R	R	S	R	R	S	R	S	S	S

S, sensitive; R, resistant; NM, not measured; ND, not detected GM-CSF, granulocyte-macrophage colony-stimulating factor.

Sensitivity to dexamethasone (Dex) or anakinra (Ana) is defined as ≥ 50% decrease in cytokine production in comparison to the appropriate antigen-restimulated control.

* Cases in which the cytokine is Dex sensitive, addition of anakinra further decreased the production by ≥ 50%.