Table 4. Relative expression of different genes expressed in lungs of mouse pups at postnatal day P14.
| Gene | Relative Expression in Double-hit untreated* | p value | Regulation | Relative Expression in Double-hit treated* | p value | Regulation |
|---|---|---|---|---|---|---|
| Sftpc# | 0.528 | 0.005 | down | 0.653 | 0.014 | down |
| Sftpb# | 0.537 | 0.030 | down | 0.471 | 0.004 | down |
| Eln | 0.735 | 0.296 | n.d. | 0.761 | 0.333 | n.d. |
| Mtor# | 0.627 | 0.008 | down | 0.746 | 0.077 | n.d. |
| Hif1a | 0.798 | 0.337 | n.d. | 0.677 | 0.054 | n.d. |
| Igf1# | 2.06 | 0.001 | up | 2.043 | <0.001 | up |
| Vegf | 0.762 | 0.206 | n.d. | 0.783 | 0.236 | n.d. |
| Tgfb1 | 1.084 | 0.718 | n.d. | 1.143 | 0.541 | n.d. |
| Tgfb2 | 1.417 | 0.159 | n.d. | 1.473 | 0.127 | n.d. |
| Tgfb3# | 0.765 | 0.135 | n.d. | 0.527 | 0.003 | down |
| Rara | 0.521 | 0.117 | n.d. | 0.693 | 0.374 | n.d. |
| Rarb | 0.998 | 0.994 | n.d. | 1.293 | 0.270 | n.d. |
| Rarg | 0.620 | 0.198 | n.d. | 0.679 | 0.252 | n.d. |
| Rbp1 | 0.826 | 0.438 | n.d. | 0.919 | 0.726 | n.d. |
| Crabp1# | 0.026 | 0.026 | down | 0.023 | <0.001 | down |
*
Relative expression was determined in relation to the expression in lungs of control normoxic mice set at 1, using the ΔΔCt-method implemented in the REST 2009 software (Qiagen, Hilden, Germany). Up: up-regulated, down, down-regulated, n.d. no difference. #Genes with significantly changed relative expression.