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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Mol Cancer Res. 2013 Jun 10;11(9):1004–1016. doi: 10.1158/1541-7786.MCR-13-0114

Figure 3. Treatment of leukemia cell lines resulted in modulation of CXCR4 cell surface expression, transcription, and localization.

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Figure 3

Cell lines were treated with chemotherapy and harvested at 10 time points over 96 hours. Surface CXCR4 and mRNA expression of CXCR4 and NRF1 were measured simultaneously by flow cytometry and qRT-PCR, respectively. The effects of (a) daunorubicin on MOLM-14, (b) cytarabine on Nalm-6, (c) vincristine on SEM-K2, and (d) vincristine on HB-1119 are shown. In additional experiments, changes in surface and intracellular CXCR4 induced by chemotherapy were measured by flow cytometry. (e) Surface and intracellular changes in CXCR4 induced by daunorubicin in MOLM-14 and (f) changes in CXCR4 induced by cytarabine in Nalm-6 are shown.