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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Eur J Pharm Biopharm. 2013 Apr 20;85(2):189–196. doi: 10.1016/j.ejpb.2013.04.003

Figure 3.

Figure 3

(I) Comparison of relaxation data determined from the TAM method at 40 °C (using MSE fitting) with the ΔTg method for the series of freeze dried formulations. The standard deviations for both relaxation times are indicated by the error bars. (II) A plot of [(ln τDβ)MSE – (ln τβ)ΔTg] versus ln (τβ)ΔTg. The dash line is the linearly fitted line (ln y = – 0.72 · ln x + 2.4; R2 = 0.86). Symbol keys for formulations; ■ - (A) HES + disaccharide (trehalose or sucrose) at total solid of 5%; ● - (B) HES 5% + sorbitol or glycerol 0-1%; △ - (C) HES 5% + trehalose 1% + sorbitol or glycerol 0-1%; ▽ - (D) HES 5% + trehalose 3% + sorbitol or glycerol 0-1% and ◇ - (E) HES 0.75% + trehalose:glycerol.