. Author manuscript; available in PMC: 2014 Oct 1.

Published in final edited form as: Eur J Pharm Biopharm. 2013 Apr 20;85(2):189–196. doi: 10.1016/j.ejpb.2013.04.003

Table 1.

Composition of HES, disaccharides and polyols in the freeze dried formulations.

Formulations	HES:Disacdiaride ratio
(A) HES + disaccharide (trehalose or sucrose) (Total solid of 5%)	5 : 0
	4 : 1
	2.5 : 2.5
	1 : 4
	0 : 5

	Amount of sorbitol or glycerol
(B) HES 5% + (C) HES 5% + trehalose 1% + (D) HES 5% + trehalose 3% + (Variable solid content, 5 – 9%)	none
	sorbitol 0.5 %
	sorbitol 1 %
	glycerol 0.5 %
	glycerol 1 %

	Trehalose:glycerol ratio, 3% total
(E) HES 0.75% + trehalose:glycerol (Total solid of 3.75%)	3 : 0
	2.91 : 0.09
	2.85 : 0.15
	2.70 : 0.30
	2.55 : 0.45