Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Pain. 2013 Jun 15;154(10):2024–2033. doi: 10.1016/j.pain.2013.06.019

Figure 6. A single intrathecal application of calcineurin provided prolonged analgesia in neuropathic animals.

Figure 6

CCI animals exhibited pain behavior seven days post-ligation. After the behavioral testing, saline or calcineurin were injected intrathecally and the animals were behaviorally retested two, four, and six days after the single injection. Both mechanical and thermal hypersensitivity were significantly attenuated in the calcineurin injected animals two and four days post-injection. By six days the pain behavior returned. Saline-injected CCI animals exhibited pain behavior throughout the six day testing period. A single intrathecal injection of calcineurin did not modify the behavior of control uninjured animals two, four and six days post-injection. *p<0.001.