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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Cancer Res. 2013 Jul 5;73(18):5821–5833. doi: 10.1158/0008-5472.CAN-13-1080

Fig. 6. ANTXR1 is essential for stemness phenotype.

Fig. 6

A) MCF-10A cells overexpressing C5A form larger and more mammospheres compared to parental cells. Mammospheres visualized upon Wright-Giemsa staining after filtering through a 40-micron filter along with photomicrographs from two fields are shown on left and numerical differences are shown in right. B) C5A overexpression leads to increased number of CD44+ MCF-10A cells. C) TMD-231 cells expressing ANTXR1 shRNA show epithelial morphology compared to parental cells, which are predominantly mesenchymal. D) TMD-231 cells expressing ANTXR1 shRNA display reduced mammosphere-forming capacity. Mammospheres visualized upon Wright-Giemsa staining (top), photomicrographs (center) and numerical differences (bottom) are shown. E) ANTXR1 knockdown leads to increased cell surface levels of EpCAM.