Table 2.
Results of hierarchical regression showing that the relationship between greater cumulative neonatal pain (adjusted for neonatal confounders) and the ratio of spontaneous gamma oscillations to alpha rhythms at age 7 years differs depending on the extent of prematurity at birth (extremely low gestational age or very low gestational age).
| Model | β | P value |
|---|---|---|
| Block 1a | ||
| Preterm group (ELGA, VLGA) | −.214 | .321 |
| Gender | −.029 | .843 |
| Number of surgeries | −.200 | .301 |
| Cumulative morphine (daily doses adjusted for weight) | −.042 | .900 |
| Illness severity day 1 SNAP II | .042 | .818 |
| Days of mechanical ventilation | .321 | .261 |
| Block 2b | ||
| Preterm group (ELGA, VLGA) | 3.577 | .043 |
| Gender | −.058 | .678 |
| Number of surgeries | −.280 | .150 |
| Cumulative morphine (daily doses adjusted for weight) | −.156 | .631 |
| Illness severity day 1 SNAP II | .079 | .652 |
| Days of mechanical ventilation | −.073 | .839 |
| Cumulative pain (number of skin breaking procedures) | 2.122 | .039 |
| Preterm group (ELGA, VLGA) × cumulative pain | −2.962 | .029 |
a
Neonatal factors associated with prematurity and cumulative pain; chart review was conducted from birth to term equivalent age.
b
Cumulative pain and the interaction of preterm group (ELGA, VLGA) × cumulative pain was added to the model.