Table 1.
Group characteristics of the study groups.
| N |
Healthy controls |
Premanifest gene carriers |
Early HD patients |
|---|---|---|---|
| 28 | 28 | 20 | |
| Gender M/F | 13/15 | 11/17 | 5/15 |
| Age (years) mean (SD) | 48.5 (8.5) | 43.21 (8.2) | 46.5 (10.6) |
| Education level Median (range) |
(2–5) | (2–5) | (1–5) |
| Handedness—right Number (% of group) |
25 (89%) | 24 (85%) | 17 (85%) |
| CAG repeat length Mean (SD) |
n/a | 42.5 (2.5) | 44.1 (2.6)b |
| Total functional capacity Mean (SD) |
12.9 (1.9) | 12.6 (0.8) | 10.2 (1.9)ab |
| UHDRS—motor Mean (SD) |
2.5 (2.5) | 2.4 (1.4) | 20.3 (11.0)ab |
| Expected disease onset (years) mean (SD) | n/a | 11.6 (4.4) | n/a |
| Disease duration (years) mean (SD) | n/a | n/a | 6.8 (7.4) |
N = number of participants, SD = Standard deviation, n/a = not applicable, UHDRS—motor = Unified Huntington's Disease Rating Scale—total motor score.
a
Significantly different to controls at p < 0.05.
b
Significantly different to premanifest gene carriers at p < 0.05.