Table 1. Increased rates of second malignancies in patients with CLL as compared with FL patients and the general population of Manitoba.

	CLL population			Compared with FL		Compared with GP
Groups	n	Time at risk (PY)	Second cancers	SIR	95% CI	SIR	95% CI
All cancers
All	255	2707.18	104	1.79a	1.30–2.45	1.93a	1.40–2.68
Male	260	1456.39	65	1.84a	1.23–2.75	2.05a	1.35–3.12
Female	195	1250.70	39	1.71a	1.02–2.84	1.76a	1.05–2.96
Invasive cancers (excluding NMSCs)
All	499	3033.02	76	1.51a	1.06–2.14	1.62a	1.13–2.32
Male	288	1662.09	45	1.19	0.77–1.82	1.59a	1.00–2.53
Female	211	1370.93	31	2.49a	1.29–4.78	1.66	0.94–2.93
NMSCs
All	538	3268.53	50	2.27a	1.38–3.74	40.42a	5.28–309.32
Male	299	1712.79	35	3.12a	1.60–6.10	38.57a	3.65–408.04
Female	239	1555.73	15	1.39	0.64–3.03	44.00	0.84–2304.23

Abbreviations: CI=confidence interval; CLL=chronic lymphocytic leukaemia; FL=follicular lymphoma; GP=general population; n=number of CLL cases; NMSCs=non-melanoma skin cancers; PY=Person-Years; SIR=standardised incidence ratio.

^aIndicates statistical significance.