Table 2. Univariate and multivariate survival analyses.

	Univariate		Multivariate analysisa
	HR (CI)	P-value	HR (CI)	P-value
Race
White	1		1
Black	1.12 (1.09–1.14)	<0.001	1.11 (1.08–1.14)	<0.001
Other	0.99 (0.96–1.02)	0.55	0.95 (0.91–0.98)	0.005
Age
<65	1		1
⩾65	1.61 (1.58–1.63)	<0.001	1.43 (1.40–1.46)	<0.001
Decade
1973–79	1
1980–89	1 (0.97–1.02)	0.69
1990–99	0.94 (0.92–0.96)	<0.001	1
2000–08	0.87 (0.85–0.89)	<0.001	0.98 (0.96–1.0)	0.03
Gradeb
1	1
2	1.29 (1.18–1.40)	<0.001
3	1.38 (1.28–1.49)	<0.001
4	1.46 (1.34–1.58)	<0.001
Sex
Male	1		1
Female	1.05 (1.04–1.07)	<0.001	0.86 (0.84–0.88)	<0.001
Radiotherapy
None	1		1
RT	0.56 (0.55–0.57)	<0.001	0.68 (0.66–0.69)	<0.001
Refused	1.04 (0.97–1.1)	0.28	0.96 (0.89–1.04)	0.28
Histology
Adeno	1		1
NOS	1.06 (1.04–1.08)	<0.001	0.94 (0.92–0.97)	<0.001
SqCC	0.39 (0.38–0.40)	<0.001	0.40 (0.38–0.41)	<0.001
Neuroendocrine	0.49 (0.47–0.52)	<0.001	0.49 (0.47–0.51)	<0.001
Pathological confirmation
Yes	1		1
No	1.72 (1.69–1.76)	<0.001	1.39 (1.35–1.44)	<0.001
Marital status
Married	1		1
Previously married	1.29 (1.27–1.31)	<0.001	1.20 (1.17–1.23)	<0.001
Single	1.11 (1.08–1.13)	<0.001	1.17 (1.14–1.21)	<0.001
Education levelc
Lowest education	1		1
Second quartile	0.97 (0.94–1.0)	0.02	0.96 (0.94–0.99)	0.01
Third quartile	0.97 (0.95–1.0)	0.02	0.97 (0.95–1.0)	0.04
Highest education	0.94 (0.92–0.96)	<0.001	0.95 (0.93–0.98)	0.001
Povertyc
Affluent	1		1
Middle	1.04 (1.02–1.06)	<0.001	1.02 (1.00–1.04)	0.05
Poor	1.02 (0.99–1.06)	0.26	1.03 (0.98–1.07)	0.25

Abbreviations: CI=confidence interval; HR=hazard ratio; NOS=not otherwise specified; RT=radiotherapy; SqCC=squamous.

^aOn the basis of 51 294 out of 56 661 patients diagnosed since 1990 with all data.

^bGrade was excluded on multivariate analysis as only 9783 patients had data for grade.

^cEducation level and poverty are for patients diagnosed since 1990.