Table 5. Multivariate analysis of clinicopathologic variables associated with disease-specific survival in women with breast cancer aged 18–39 years in Asian subgroups with a sample size of >500 using a Cox proportional hazards model.
| |
Filipino (n=1040) |
Chinese (n=995) |
Japanese (n=602) |
Hawaiian/Pacific Islander (n=540) |
||||
|---|---|---|---|---|---|---|---|---|
| Variable | HR | P-value | HR | P-value | HR | P-value | HR-value | P-value |
|
Disease stage | ||||||||
| Localised | Referent | |||||||
| Regional | 2.8 | <0.001 | 3.25 | <0.001 | 4.11 | <0.001 | 3.92 | <0.001 |
| Distant |
10.3 |
<0.001 |
16.9 |
<0.001 |
9.44 |
<0.001 |
4.37 |
0.01 |
|
Tumour grade | ||||||||
| I | Referent | |||||||
| II | NS | 1.96 | 0.3 | NS | NS | |||
| III | NS | 2.77 | 0.09 | NS | NS | |||
| IV |
|
NS |
4.35 |
0.046 |
|
NS |
|
NS |
|
Histology | ||||||||
| IDC | Referent | |||||||
| ILC | NS | 7.32 | 0.001 | NS | NS | |||
| IDC and ILC | NS | 0.57 | 0.2 | NS | NS | |||
| Others |
|
NS |
1.09 |
0.7 |
|
NS |
|
NS |
|
Negative ER status |
|
NS |
|
NS |
|
NS |
2.02 |
0.003 |
|
Negative PR status |
|
NS |
|
NS |
|
NS |
|
NS |
|
Age <35 years |
|
NS |
|
NS |
|
NS |
|
NS |
|
Adjuvant radiation therapy |
|
NS |
|
NS |
|
NS |
|
NS |
|
Primary surgery | ||||||||
| SM | Referent | |||||||
| TM | 1.70 | 0.002 | NS | NS | 1.92 | 0.02 | ||
| None | 4.84 | <0.001 | NS | NS | 7.46 | 0.004 | ||
Abbreviations: ER=oestrogen receptor; HR=hazard ratio; IDC=invasive ductal cancer; ILC=invasive lobular cancer; NS=not significant; PR=progesterone receptor; SM=segmental mastectomy; TM=total mastectomy;