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. 2013 Aug 6;109(5):1252–1263. doi: 10.1038/bjc.2013.439

Figure 7.

Figure 7

The Pyk2 upregulates CSC marker expression and transforming ability in NSCLC cells. (A) Overexpression of Pyk2 upregulated the expression of the CSC markers ALDH1a1, ABCG2 and Bmi1 at the protein level in A549 and H460 cells. (B) Knockdown of Pyk2 downregulated the expression of the CSC markers ALDH1a1, ABCG2 and Bmi1 at the protein level in A549 and H460 cells. (C) Anchorage-independent growth in soft agar of A549 and H460 cells with or without exogenous Pyk2 expression. (D) Anchorage-independent growth in soft agar of A549 and H460 cells with Pyk2 shRNA or scrambled shRNA. Three independent experiments in triplicate were performed. Magnification: × 40. Error bars represent the s.e.m.