Table 4. Factors associated with non-compliance in the re-excision group (N=198).
| |
|
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|---|
| Compliant decisions N=170,N (%) | Non-compliant decisions N=28,N (%) | P-value | OR (95% CI) | P-value | |
|
Age at diagnosis, years |
|
|
0.4 |
|
|
| ⩽35 | 5 (71.4) | 2 (28.6) | |||
| 35–80 | 153 (86.4) | 24 (13.6) | |||
| ⩾80 |
12 (85.7) |
2 (14.3) |
|
|
|
|
Postmenauposal status |
|
|
0.7 |
|
|
| No | 68 (87.2) | 10 (12.8) | |||
| Yes |
100 (84.8) |
18 (15.2) |
|
|
|
|
Tumour size, mm |
|
|
0.3 |
|
|
| ⩽20 | 131 (85.1) | 23 (14.9) | |||
| 20–40 | 33 (91.7) | 3 (8.3) | |||
| ⩾40 |
6 (75.0) |
2 (25.0) |
|
|
|
|
Multifocal tumour |
|
|
0.1 |
|
|
| No | 113 (89.0) | 14 (11.0) | |||
| Yes |
57 (80.3) |
14 (19.7) |
|
|
|
|
Microinvasive tumour |
|
|
0.04 |
|
|
| No | 160 (87.4) | 23 (12.6) | 1 | ||
| Yes |
10 (66.7) |
5 (33.3) |
|
5.2 (1.5–17.5) |
0.008 |
|
Prior neoadjuvant treatment |
|
|
0.1 |
|
|
| No | 160 (87.0) | 24 (13.0) | 1 | ||
| Yes |
10 (71.4) |
4 (28.6) |
|
4.2 (1.1–15.1) |
0.03 |
|
Frequent patient profile |
|
|
0.1 |
|
|
| No | 106 (82.8) | 22 (17.2) | |||
| Yes |
64 (91.4) |
6 (8.6) |
|
|
|
|
Surgical discovery of microinvasion |
|
|
0.09 |
|
|
| No | 155 (87.6) | 22 (12.4) | 1 | ||
| Yes |
15 (71.4) |
6 (28.6) |
|
4.2 (1.4–12.5) |
0.01 |
|
Prior breast surgery |
|
|
0.5 |
|
|
| Lumpectomy | 154 (86.5) | 24 (13.5) | |||
| Mastectomy |
16 (80.0) |
4 (20.0) |
|
|
|
|
Recommended re-excision by mastectomy |
|
|
0.8 |
|
|
| No | 93 (86.9) | 14 (13.1) | |||
| Yes | 60 (84.5) | 11 (15.5) | |||
| Already done |
17 (85.0) |
3 (15.0) |
|
|
|
|
<3 mm margins
(in situ
component) |
|
|
1.0 |
|
|
| No | 111 (86.1) | 18 (13.9) | |||
| Yes |
59 (85.5) |
10 (14.5) |
|
|
|
|
<3 mm margins (invasive component) |
|
|
0.6 |
|
|
| No | 134 (86.4) | 21 (13.6) | |||
| Yes |
36 (83.7) |
7 (16.3) |
|
|
|
|
Prior axillary surgery |
|
|
0.6 |
|
|
| Sentinel node procedure | 112 (87.5) | 16 (12.5) | |||
| Axillary lymphadenectomy | 30 (83.3) | 6 (16.7) | |||
| No axillary surgery |
28 (82.4) |
6 (17.6) |
|
|
|
|
Sentinel node status |
|
|
0.01 |
|
|
| Negative | 58 (80.6) | 14 (19.4) | |||
| Positive | 54 (96.4) | 2 (3.6) | |||
| No sentinel node procedure | 58 (82.9) | 12 (17.1) | |||
Abbreviations: CI=confidence interval; OR=odds ratio.
Two missing data for postmenopausal status in compliant decisions. Fisher's exact test used for categorical variables in the univariate analysis. Variables with P<0.20 in the univariate analysis (multifocal tumour, microinvasive tumour, prior neoadjuvant treatment, frequent patient profile, surgical discovery of microinvasion, and sentinel node status) entered the multivariate analysis.