Table 1. Characteristics of patients.
| |
Locally advancedn
(%) |
Metastaticn
(%) |
|---|---|---|
| Characteristics | n=9 | n=12 |
|
Age (years) | ||
| Median | 57 | 63 |
| Range |
23–71 |
31–73 |
|
Sex | ||
| Male | 3 (33) | 4 (33) |
| Female |
6 (67) |
8 (67) |
|
Performance status | ||
| 0 | 5 (56) | 5 (42) |
| 1 |
4 (44) |
7 (58) |
|
Primary tumour localisation | ||
| Gland of palate | 4 (44) | 2 (17) |
| Lacrimal gland | 1 (11) | 1 (8) |
| Submandibular gland | — | 2 (17) |
| Maxillary sinus gland | 1 (11) | 2 (17) |
| Parotid gland | — | 2 (17) |
| Base of tongue | 1 (11) | — |
| Nasopharynx | — | 2 (17) |
| Lung | — | 1 (8) |
| Tracheal gland |
2 (22) |
— |
|
Metastasis localisation | ||
| Lung | — | 3 |
| Lymph node | — | 2a |
| Skin | — | 1 |
| Multiple |
— |
6 |
|
Histology | ||
| Cribriform | 4 (44) | — |
| Solid | 1 (11) | 1 (8) |
| Tubular | — | 1 (8) |
| Mixed | 2 (22) | 2 (17) |
| NA |
2 (22) |
8 (67) |
|
Grade | ||
| 1 | 3 (33) | 1 (8) |
| 2 | 2 (22) | 2 (17) |
| 3 | 2 (22) | 1 (8) |
| NA |
2 (22) |
8 (67) |
|
Perineural invasion | ||
| Yes | 2 (22) | 2 (17) |
| No | 5 (56) | 3 (25) |
| NA |
2 (22) |
7 (58) |
|
Tumour stage at diagnosis | ||
| T1 | — | 2 (16) |
| T2 | 1 (11)b | 4 (33) |
| T3 | 2 (22)b | 3 (25) |
| T4a | — | 1 (8) |
| T4b |
6 (67)c |
2 (17) |
|
Nodal stage at diagnosis | ||
| N0 | 9 (100) | 9 (75) |
| N1 |
— |
3 (25) |
|
Disease stage at enrollment | ||
| Stage I | 1 (11) | — |
| Stage II | 2 (22) | — |
| Stage IVA | 6 (67) | — |
| Stage IVC |
— |
12 (100) |
|
Site of progression | ||
| Lung | 1 (11) | 6 (50) |
| Local | 4 (44) | — |
| Skin | 1 (8) | |
| Dura | 1 (8) | |
| Bone | 1 (8) | |
| Orbit |
|
1 (8) |
|
EGFR status | ||
| 2+ | 6 (67) | 8 (67) |
| 3+ |
3 (33) |
4 (33) |
|
Best response | ||
| CR | 2 (22) | — |
| PR | 2 (22) | 5 (42) |
| SD ⩾18 months | 2 (22) | 5 (42) |
| SD <18 months | 3 (33) | 2 (17) |
| PD | — | — |
Abbreviations: CR=complete response; EGFR=epidermal growth factor receptor; NA=not available; PD=progressive disease; PR=partial response; SD=stable disease.
a
Mediastinal and mediastinal+cervical.
b
Refused surgery.
c
Unresectable.