Table 3. Summary of docetaxel pharmacokinetics.
| Visit | Patient | Tmax (h) | Cmax(ng ml−1) | AUClast(h*ng ml−1) | AUCINF(h*ng ml−1) | Cl (L h−1) | Vz (L) | Half-life (h) | MRTINF (h) |
|---|---|---|---|---|---|---|---|---|---|
| C1D1 |
N |
43 |
43 |
43 |
43 |
43 |
43 |
43 |
43 |
| |
Mean |
0.19 |
799.12 |
1203.79 |
1530.81 |
143.66 |
2993.46 |
14.89 |
15.23 |
| |
SE |
0.02 |
146.59 |
235.49 |
270.84 |
10.98 |
273.91 |
1.12 |
1.65 |
| |
CV% |
56.1 |
120.3 |
128.3 |
116 |
50.1 |
60 |
49.3 |
70.9 |
| C2D1 |
N |
35 |
35 |
35 |
35 |
35 |
35 |
35 |
35 |
| |
Mean |
0.19 |
538.86 |
850.85 |
1106.26 |
154.1 |
2691.45 |
13.14 |
13.89 |
| |
SE |
0.02 |
60.66 |
88.15 |
127.4 |
15.23 |
235.19 |
0.87 |
1.08 |
| CV% | 48.1 | 66.6 | 61.3 | 68.1 | 58.5 | 51.7 | 39 | 46.1 |
Abbreviations: AUC=area under the curve; C=cycle; Cl=clearance; CV=coefficient of variance; INF=infinity; D=day; MRT=mean resonance time; SE=standard error; Vz=volume of distribution.