Table 4. Pharmacokinetic parameters of PX-866 metabolites (17-OH-PX-866 and 17-diOH-PX-866) from patient plasma samples following treatment with 8 mg PX-866 at cycle 1 day 8.
|
17-OH-PX-866 | ||||||
|---|---|---|---|---|---|---|
| Visit | Patient | Half-life (h) | AUClast (h*ng ml−1) | AUCINF (h*ng ml−1) | Tmax (h) | Cmax(ng ml−1) |
| C1D8 |
N |
13 |
18 |
13 |
18 |
18 |
| |
Mean |
1.93 |
5.12 |
5.77 |
2.19 |
2.39 |
| |
SE |
0.26 |
1.04 |
1.22 |
1.29 |
0.6 |
| |
CV% |
48.7 |
85.9 |
76.3 |
250 |
106.5 |
| C2D1 |
N |
14 |
18 |
14 |
18 |
18 |
| |
Mean |
10.33 |
5.09 |
4.58 |
2.44 |
1.39 |
| |
SE |
3.85 |
1.42 |
1.25 |
1.29 |
0.37 |
| |
CV% |
139.5 |
118 |
102.1 |
224 |
111.9 |
|
11,17-diOH-PX-866 | ||||||
| C1D8 |
N |
3 |
13 |
3 |
13 |
13 |
| |
Mean |
1.58 |
1.58 |
2.47 |
1.44 |
0.48 |
| |
SE |
0.3 |
0.47 |
0.79 |
0.25 |
0.12 |
| |
CV% |
32.6 |
106.4 |
55.5 |
62.4 |
88.4 |
| C2D1 |
N |
1 |
8 |
1 |
8 |
8 |
| |
Mean |
1.85 |
2.08 |
1.79 |
7.08 |
0.25 |
| |
SE |
NA |
0.66 |
NA |
3.7 |
0.05 |
| CV% | NA | 89.6 | NA | 147.6 | 56.3 | |
Abbreviations: AUC=area under the curve; C=cycle; Cl=clearance; CV=coefficeint of variance; D=day; INF=infinity; NA=not available; SE=standard error.