Table 2.
Phenol nucleophile scope.
![]() | ||||||
| Entry | Equiv 5 | Temp. (°C) | Time (h) | Phenol 5 | Product | Yield (%)a |
| 1 | 5 | 50 | 19 |
![]() 5a |
![]() 8a |
64 |
| 2 | 5 | 50 | 64 |
![]() 5b |
![]() 9b |
N/Db |
| 3 | 5 | 60 | 18 |
![]() 5b |
![]() 8b |
57 |
| 4 | 2 | 60 | 17 |
![]() 5c |
![]() 8c and 8c' |
71 (~1:1 8c:8c') |
| 5 | 5 | 60 | 18 |
![]() 5d |
![]() 8d |
69 |
| 6 | 5 | 60 | 17 |
![]() 5e |
![]() 8e |
63 |
| 7 | 2 | 60 | 17 |
![]() 5f |
![]() 8f |
71 |
| 8 | 2 | 60 | 18 |
![]() 5g |
![]() 8g |
54 |
| 9 | 5 | 60 | 17 |
![]() 5h |
![]() 8h |
58 |
| 10 | 2 | 60 | 17 |
![]() 5i |
![]() 8i |
57 |
| 11 | 5 | 70 | 43 |
![]() 5j |
![]() 8j |
83 |
| 12c | 5 | 70, 48 h; 80, 17 h |
65 |
![]() 5k |
![]() 8k |
69 |
| 13c,d | 5 | 90 | 65 |
![]() 5l |
![]() 8l |
83 |
aIsolated yield. bNot determined. cSolvent: dioxane. dReaction carried out in sealed tube.


























