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. 2013 Sep 4;9:1797–1806. doi: 10.3762/bjoc.9.209

Table 2.

Phenol nucleophile scope.

graphic file with name Beilstein_J_Org_Chem-09-1797-i002.jpg

Entry Equiv 5 Temp. (°C) Time (h) Phenol 5 Product Yield (%)a

1 5 50 19 Inline graphic
5a
Inline graphic
8a
64
2 5 50 64 Inline graphic
5b
Inline graphic
9b
N/Db
3 5 60 18 Inline graphic
5b
Inline graphic
8b
57
4 2 60 17 Inline graphic
5c
Inline graphic
8c and 8c'
71
(~1:1 8c:8c')
5 5 60 18 Inline graphic
5d
Inline graphic
8d
69
6 5 60 17 Inline graphic
5e
Inline graphic
8e
63
7 2 60 17 Inline graphic
5f
Inline graphic
8f
71
8 2 60 18 Inline graphic
5g
Inline graphic
8g
54
9 5 60 17 Inline graphic
5h
Inline graphic
8h
58
10 2 60 17 Inline graphic
5i
Inline graphic
8i
57
11 5 70 43 Inline graphic
5j
Inline graphic
8j
83
12c 5 70, 48 h;
80, 17 h
65 Inline graphic
5k
Inline graphic
8k
69
13c,d 5 90 65 Inline graphic
5l
Inline graphic
8l
83

aIsolated yield. bNot determined. cSolvent: dioxane. dReaction carried out in sealed tube.