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. 2013 May 28;4(9):1256–1266. doi: 10.1021/cn4000428

Figure 4.

Figure 4

Antinociceptive tolerance development for morphine and UMB 425 for the hot plate and tail-flick assays. Male, Swiss Webster mice were given an ED90 dose of morphine (15 mg/kg, s.c.) or UMB 425 (15 mg/kg, s.c.) twice daily for a 5 day period. Latencies were determined 30 min after drug administration. (a) Antinociceptive tolerance development in the hot plate assay. **p < 0.01 vs Morphine Day 1/UMB 425 Day 1; #p < 0.05 vs Morphine Day 4; ###p < 0.001 vs Morphine Day 5. (b) Antinociceptive tolerance development in the tail-flick assay. *p < 0.05, **p < 0.01 vs Morphine Day 1; #p < 0.05 vs Morphine Day 5.