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| ED50 (mg/kg) |
||
|---|---|---|
| morphine | UMB 425 | |
| hot plate | 2.73 | 4.30 |
| tail-flick | 6.85 | 8.83 |
Summary of antinociceptive activity of acute morphine (0.1–20 mg/kg, s.c.) and UMB 425 (0.1–20 mg/kg, s.c.) treatment in Swiss Webster mice for the hot plate and tail-flick assays. Respective ED50 values (in mg/kg, s.c.) were obtained at the 30 min time point after drug administration.
