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. 2013 Jun 3;4(9):1322–1332. doi: 10.1021/cn400116z

Figure 2.

Figure 2

Evaluation of NHS carbamates as serine hydrolase inhibitors. (A) Structures of representative members of NHS carbamate library. (B) In vitro evaluation of NHS carbamates as serine hydrolase inhibitors in mouse brain (membrane) proteomes showing inhibition of multiple serine hydrolases including MAGL, FAAH, ABHD6, LYPLA1/2, and APEH (enzyme identities were assigned based on gel migration patterns consistent with previous studies3b,3c,29). See Figure S1 for full compound list and ABPP gel profiles.