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. 2013 Jul 30;4(9):1249–1255. doi: 10.1021/cn400132u

Figure 4.

Figure 4

Prepulse inhibition (PPI) performance in sham and 6-OHDA-treated animals. Sham-lesioned animals demonstrated a normal inhibition of the startle response with increased prepulse intensity (i.e., increased % prepulse inhibition). Two-way ANOVA revealed significant main effects of treatment condition and prepulse intensity. Bonferroni post hoc analyses for repeated measures showed that vehicle-6-OHDA animals showed impaired PPI at all prepulse intensities compared with sham controls (*p < 0.05). Pretreatment with estradiol, AC-131, AC-186, AC-623, or AC-957 prevented the 6-OHDA-induced deficits in PPI (+p < 0.05 vs vehicle-treated 6-OHDA lesioned animals). Data were analyzed using repeated measures two-way ANOVA followed by Bonferonni’s multiple comparison post hoc analyses.