Table 1.
Class II/HERV-K (human MMTV-like) families.
| Name | Alternative names | Estimated time of integration (mya) | Estimated copy number in genome |
Reference | |
|---|---|---|---|---|---|
| Proviruses | Solo LTRs* | ||||
| HML-1 | NMWV6, HERV-K14I | ∼39 | 68 | 350 | Franklin et al. (33), Medstrand and Blomberg (34), Flockerzi et al. (41) |
| HML-2 | NMWV1, HDTV | ∼35–2 | 91 | 944 | Subramanian et al. (4), Bannert and Kurth (24), Ono (42) |
| HML-3 | NMWV5, HERV-K9I | ∼36 | 140 | 700 | Franklin et al. (33), Medstrand and Blomberg (34), Mayer and Meese (43) |
| HML-4 | HERVK13I, HERV-K-T47D | ∼55–35 | 5 | 800 | Medstrand and Blomberg (34), Seifarth et al. (37) |
| HML-5 | NMWV2, HERV-K22I | ∼55 | 139 | 600 | Franklin et al. (33), Lavie et al. (40) |
| HML-6 | NMWV4, HERV-K3I | ∼30 | 30–40 | 50 | Franklin et al. (33), Medstrand et al. (44), Yin et al. (45) |
| HML-7 | NMWV7, HERV-K11D1 | n.d. | 20 | 140 | Franklin et al. (33), Andersson et al. (35) |
| HML-8 | NMWV3, HERV-K11I | n.d. | 60 | 600 | Franklin et al. (33), Andersson et al. (35) |
| HML-9 | NMWV9 | n.d. | 10 | 40 | Franklin et al. (33), Andersson et al. (35) |
| HML-10 | HERV-K(C4) | ∼30 | 10–50 | 100 | Jern et al. (31), Tassabehji et al. (46) |
* Most copy numbers of solo LTRs given in Ref (24); mya, million years ago; n.d., not determined.