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. Author manuscript; available in PMC: 2014 Sep 6.
Published in final edited form as: J Org Chem. 2013 Aug 13;78(17):8859–8864. doi: 10.1021/jo401249y

Table 1.

Bench-scale (0.5 mmol) results from selected HTE leads.graphic file with name nihms-513605-t0001.jpg

entry ligand solvent equiv MeNO2 L:Pd P:SM at 5 ha yield (%)b
1 cataCXium
POMetB		 THF 2 2:1 93:7 66c
2 cataCXium
POMetB		 1,4-dioxane 2 2:1 89:11 67c
3 XPhos THF 2 2:1 67:33 42
4 XPhos 1,4-dioxane 2 2:1 59:41 81
5 XPhos 1,4-dioxane 5 2:1 90:10 85
6 XPhos 1,4-dioxane 10 2:1 90:10 92
7 XPhos 1,4-dioxane 2 1.2:1 62:38 79
a

Determined by GC.

b

Yield after column chromatography.

c

9 h reaction time.