Table 1.

Mean ± SD and range for pharmacokinetic parameters for unbound (plasma) and total (serum) platinum after a single intratumoral injection of a hyaluronan nanocarrier (approx 1.5 mL) conjugated with 20 mg of cisplatin to 5 dogs with STSs.

	Unbound platinum		Total platinum
Parameter	Mean ± SD	Range	Mean ± SD	Range
AUC (ng•h/mL)	774.6 ± 222.1	556.9−1,147.1	3,562.1 ± 2,031.1	1,457.5−6,502.4
Cmax (ng/mL)	56.5 ± 20.9	22.9−71.0	81.6 ± 40.4	38.0−142.0
T1/2 (h)	33.6 ± 16.1	24.2−62.1	51.2 ± 29.1	27.5−99.1