TABLE 2.
AVERAGE CHANGE IN LUNG CLEARANCE INDEX BETWEEN BASELINE AND FOLLOW-UP FOR EACH TREATMENT GROUP AND THE RELATIVE TREATMENT EFFECT IN THE HYPERTONIC SALINE GROUP COMPARED TO THE ISOTONIC SALINE GROUP, AND AVERAGE CHANGE IN Z-SCORE–STANDARDIZED LUNG CLEARANCE INDEX (15)
| n | Hypertonic Saline | SD | P Value | n | Isotonic Saline | SD | P Value | Treatment Effect | P Value | |
|---|---|---|---|---|---|---|---|---|---|---|
| LCI |
|
|
|
|
|
|
|
|
|
|
| Overall |
12 |
−1.20 (−2.29 to −0.12) |
2.0 |
0.030 |
13 |
0.23 (−0.90 to 1.35) |
2.1 |
0.693 |
1.43 (−0.13 to 2.99) |
0.073 |
| Infant |
4 |
0.19 (−0.92 to 1.30) |
1.2 |
0.737 |
6 |
1.03 (0.11 to 1.95) |
1.2 |
0.028 |
0.84 (−0.60 to 2.28) |
0.251 |
| Preschool |
8 |
−1.90 (−3.19 to −0.60) |
1.9 |
0.004 |
7 |
−0.47 (−2.27 to 1.34) |
2.5 |
0.613 |
1.43 (−0.79 to 3.65) |
0.206 |
| zLCI |
|
|
|
|
|
|
|
|
|
|
| Overall |
12 |
−1.19 (−2.46 to 0.06) |
2.5 |
0.063 |
13 |
0.81 (−0.40 to 2.02) |
2.1 |
0.191 |
2.01 (0.26 to 3.76) |
0.025 |
| Infant |
4 |
0.44 (−1.12 to 1.99) |
1.7 |
0.583 |
6 |
1.86 (0.59 to 3.13) |
1.8 |
0.004 |
1.42 (−0.59 to 3.44) |
0.165 |
| Preschool | 8 | −2.02 (−3.53 to −0.51) | 2.5 | 0.009 | 7 | −0.09 (−1.70 to 1.52) | 2.1 | 0.912 | 1.93 (−0.28 to 4.14) | 0.087 |
Definition of abbreviations: LCI = lung clearance index; zLCI = LCI standardized to a z score.
Results were stratified for the infant and preschool groups. SD derived from the average change in LCI and zLCI. Results for treatment groups reported as mean and 95% confidence interval for the average change in LCI and zLCI.