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The structure of the DBL6ɛ domain of VAR2CSA. (a) The VAR2CSA protein consists of six extracellular DBL domains, followed by a single transmembrane helix and a cytoplasmic acidic terminal sequence (ATS). (b) Orthogonal views of the DBL6ɛ domain (residues 2350–2634) with subdomain 1 in yellow, subdomain 2 in orange and subdomain 3 in red. Green stars represent the position of residue 2480.
