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. 2013 Mar 18;23(6):496–500. doi: 10.1016/j.cub.2013.02.008

Figure 3.

Figure 3

Skin Biopsies

Left: confocal images of skin biopsies taken from the dorsum of the hand and fingertip, demonstrating PGP 9.5-immunoreactive fibers (red) crossing the basement membrane (labeled with type IV collagen fibers, green). Arrows indicate fibers crossing into the epidermis. Scale bars represent 50 μm. Right: intraepidermal nerve fiber density (IENFD, fiber count/mm) in the dorsum of the hand and in the fingertip. Note the clear proximal-to-distal decrease in IENFD in all participants.