Figure S3.

Casodex Treatment of K14MycER Mice, Related to Figure 4

(A–K) Back skin of K14MycER mice (Myc:) was stained with H&E (A, B, and F) or labeled with the antibodies shown (D, E, I, and J). Skin in (I) was from a cross with AR-TFM. White brackets in (D) indicate differences in size of individual sebocytes. (C, G, and K) Quantitation of SG differentiation compartment. (H) Schematic summary of changes relative to WT SG of treating K14MycER mice with high dose 4OHT in the presence or absence of casodex. See Figure 1N for stages in sebocytes differentiation. Increases in cell number are represented by +, ++ or +++, according to the strength of the effect. Reduction in cell number is represented by -.

3-5 mice were examined per condition. Error bars represent SEM. NS = not significant, ^∗p < 0.05. Scale bars 40 μm.