Fig. 8.

Modification of voltage-dependent opening and closing of the common gate is sufficient to describe functional alterations by disease-associated sequence variants. a Dependence of slow activation time constants at −160 mV for WT and G715E channels. Experimental values are plotted as open squares or triangles, respectively. Lines are computed following the scheme with values stated in Table 3. b Slow time constants of activation across all voltages analyzed are well described by the seven-state model used and can be modified to represent the G715E mutant