Fig. 3. Accessibility elements at individual V_H genes divide the Igh locus into 4 domains.

For each V_H gene, all mapped reads were summed to calculate the signal intensity for each element indicated on the right starting from 1 kb upstream of the leader to 1 kb downstream of the RSS. The leader was estimated as 200 bp from the start of the coding region. Charts in the left column are values for the active (rearranging) genes and charts in the right column are those of the inactive (not rearranging) genes. Domains are represented in a bar beneath each column, and shaded and clear areas mark the four domains of the V_H gene locus. Signal intensities beyond the y-axis range are indicated with the value.